From Google answering “does the adenovirus enter the nucleus?”
Answer:
Adenovirus targets its genome to the cell nucleus by a multistep process involving endocytosis, membrane penetration and cytoplasmic transport, and finally imports its DNA into the nucleus.
The ADENOVIRUS itself should NOT enter the nucleus. It’s genome should. The virus itself should only get as far as the cellular fluid, and then, through a series of steps, it’s GENOME enters the nucleus.
Is that what you’re saying? Because those aren’t the words you used.
Yes, the viral DNA which is what makes the adenovirus vector vaccines functional. It has to go into the nucleus..
You should probably read the actual study. The journalist obviously understood it poorly and conveyed his confusion in his writing.
https://www.researchsquare.com/article/rs-558954/v1
Here, we present first molecular evidence that vector-based vaccines encoding the Spike protein exhibit a problem that is completely absent in mRNA-based vaccines. This is due to the fact that during the vaccination step, the adenoviral DNA enters the nucleus and use the host machinery to transcribe its (trans)genes inside the nucleus.