He had a bad reaction to the first shot, but went ahead and got the second shot, and the reaction was even worse.
“Fool me once, shame on you. Fool me twice, shame on me.”
My mother had a very bad reaction to the first Pfizer shot. She had formerly been very active with an exercise routine that included walking miles a day. Within a few days she could not even make it to the bathroom without assistance. And said that she was in so much pain that she just wished that she could die. Nothing her doctors did for her seemed to help. She lost a lot of weight to the point that we thought she was going to die. She managed to get a little better for a while, but now she seems to be getting weaker again and talking nonsense part of the time.
Her doctors told her under no circumstances should she ever consider getting the second shot. I assume Clapton made some attempt to contact a doctor about his issues.
Clapton's physicians must be complete idiots if they recommended that he get the second shot.