With a pistol very unlikely. With a shotgun much easier but the hand would also be gone.
I like Paul Harrell's videos. He's very careful with his tests and provides good data.
The problem is that the hand is not always broadly exposed that way. It’s twisthing and turning, and doing a LOT more erratic movement than in the video. But it still makes the point. I watched it through. What we saw there was actual scientific method in action.
BTW, we have carpenter bees where I live. It’s very difficult to smack them down with a tennis racket because they move erratically. You’d think it would be easy, but it’s not. Same principle. I prefer to wait until they just hover, though I’ve gotten good at anticipating their moves sometimes.
I’m OK with that. What about a revolver firing a .410 gauge shell, perhaps containing metallic shrapnel? If only one existed....