Amazing Spider-Man #74 goes on sale on September 22 and will feature a cover by Patrick Gleason seen here and likely many to-be-announced variant covers. Marvel is promising more news about the "next era" of Spider-Man next week, likely meaning the identity of the new writer and/or whole creative team.
As for the story being told in the new era of Amazing Spider-Man, it all revolves around Ben Reilly returning to the mantle of Spider-Man in the absence of Peter Parker. Peter's fate hasn't been revealed, but art included in Marvel's announcement seems to indicate that, as previously hinted, he'll be physically out of the picture.The included art shows Peter in a hospital bed in his tattered Spider-Man costume with Mary Jane watching over him - potentially implying he's either in a coma or worse, on his deathbed.
