“most occurred in people older than 65 or with underlying health conditions.”
And there’s the obvious answer to poor immune response to the vaccine.
Why bother compounding the problem, if your older, by taking part in the experiment.
“31.3 % of the elderly had no detectable neutralizing antibodies” That’s one out of three...:-(
https://www.medrxiv.org/content/10.1101/2021.03.03.21251066v1
Results: While the majority of participants in both groups produced specific IgG antibody titers against SARS-CoV-2 spike protein, titers were significantly lower in elderly participants. Although the increment of antibody levels after the second immunization was higher in elderly participants, the absolute mean titer of this group remained lower than the <60 group. After the second vaccination, 31.3 % of the elderly had no detectable neutralizing antibodies in contrast to the younger group, in which only 2.2% had no detectable neutralizing antibodies.
Conclusion: Our data suggests that lower frequencies of neutralizing antibodies after BNT162b2 vaccination in the elderly population may require earlier revaccination to ensure strong immunity and protection against infection.