Here’s my bottom line concern:
It’s important to discover how long these vaccines can maintain their potency. Is it possible that they would work like a measles vaccine and last a lifetime? Or will it be more like a flu vaccine where a patient would need a yearly shot? If the vaccine needs a yearly dose to be effective, some future vaccines might not.
Not a chance immunity would last a lifetime. The efficacy duration will be measured in months. Here is some data from one study:
“One dose helped protect against hospitalization, with effectiveness peaking about five weeks after immunization at 84% effective at preventing hospitalization.
But the follow-up data available beyond that time is where it gets concerning. Effectiveness peaked and then began to decline, going from 84% effective in the fifth week to 61% effective the following week and then 58% beyond then.
It’s unknown whether that trend would continue beyond that, as that’s all the data the researchers had available to crunch in the study. But the findings suggest that protection starts to wane from a single dose after five weeks or so.”
Here is a link to an Israeli chart which shows the decline in efficacy after the second shot.
https://twitter.com/dvir_a/status/1364240578922360833/photo/1
At a recent investor conference Pfizer said annual vaccination would be necessary and additional booster shots may be given.