Low levels of neutralizing antibodies plus variant that shows a degree of immunity to neutralizing antibodies produced by vaccine equals recipe for antibody dependent enhancement. This very close to what we see with dengue fever virus which has 4 variants. the first case of Dengue is usually the most mild form of the disease. The second time you get it, it is frequently the most deadly form of the disease and this is linked to A) decreased neutralizing antibodies and B) coming into contact with one of the different variants the second time.
Engrish preeze. What does that mean for the vaccine? Taking it once will create resistant virus? Or a body becomes resistant to the second dose? Don’t quite understand what it implies?