The DOJ tried to sue Fedex for not monitoring shipments of prescription drugs from Doctors who allegedly overprescribed pain killers. Fedex would had to have literally opened every package and inspected the contents of all packages in the U.S. and kept records of who shipped what. Nothing in the law made Fedex responsible for the contents of shipments and certainly no law required them to monitor who shipped what items. Fedex hung tough and insistend on going to trial, at which point the DOJ backed down.
On the other hand, I’ve seen many successful prosecutions of opioid crimes in the DOJ’s website for 2 years now which have taken down substantial opioid distributors responsible for countless deaths.