The Constitution is dead already. Countless politicians, alleged republicans and/or conservatives - many right here on FR - claiming some issue or situation is unconstitutional routinely support some other issue or situation that is clearly unconstitutional.
Follow the Sanctuaries for illegal aliens model. Anything liberals mandate, reject it as a city or state. No need to secede, but make it illegal to cooperate with liberals in power. For example, Second Amendment Sanctuaries already exist.