If you want to get rid of pythons, put a bounty on them, regardless of size. If you make it profitable, people will hunt, trap and kill pythons.
Once the python population is thinned out and people stop hunting them because it’s more difficult, then increase the bounty.
The reason I say bounty at any size or age is because you are helping the Eco-system when they are terminated young.
Bounty wouldn’t work - folks would start raising them domestically to turn in for the bounty...