[Eagles6]

A .22 Hornet is a centerfire with the velocity of a .22 Manum.

5.56 × 45 is, essentially a .22 caliber.

That said, shot placement is key.

Everything on the planet has been killed with a .22 LR.

[Cold Heart]

.22 mag 1700 fps 300 ft lbs
.22 Hornet 2700 fps 700 ft lbs