3 Coronavirus Vaccines in Phase 3 Clinical Studies: How They Stack Up Against Each Other

Motley Fool ^ | 09/18/2020 | Keith Speights

[Seruzawa]

Moderna has received commitments of up to $2.48 billion

In July, Pfizer and BioNTech agreed to provide 100 million doses of their coronavirus vaccine to the U.S. government for $1.95 billion.

Well, the coronavirus is becoming a real boon for the auto and yacht companies. Real estate too. I wonder how many Harleys the taxpayers have bought as well.

[CondorFlight]

Who’s going to use the 100 million doses?

I doubt there are 50 million adults in this country who want the vaccine (and lots more who won’t want their children to take it)

[catnipman]

Well, at least the article admits that all three of those quickie COVID "vaccines" inject a live, synthetic virus (or synthetic messenger RNA) programmed to invade the cells in our body and hijack their protein production machinery, namely the ribosomes ...

None of the current quickie COVID vaccines are really vaccines in the traditional sense of a vaccine that injects target virus fragments (antigens) that the body reacts to by making protective antibodies.

Instead, what these quickie "vaccines" really are is a giant gene therapy experiment to be conducted simultaneously on billions of people. Instead of the actual target virus fragments (antigens), what will be injected is a live, laboratory-made synthetic virus/plasmid/mRNA that contains spliced-in DNA/RNA of COVID target virus fragments (antigens) so that your own body itself will manufacture the target virus fragments (antigens) when the synthetic virus/plasmid/mRNA enters your cells and hijacks their protein-production machinery, with the body subsequently producing the protective COVID antibodies to the self-made COVID target virus fragments (antigens).

Heretofore, such recombinant DNA/RNA techniques first mixes the synthetic virus/plasmid/mRNA into a bioreactor containing living cells where the synthetic virus/plasmid/mRNA invades the cells, multiplies, hijacks the cell machinery, and produces the target virus fragments (antigens) encoded in the synthetic virus/plasmid/mRNA. The manufactured target virus fragments (antigens) are then extracted and purified. These virus fragments (antigens) in turn are the only active ingredient in the vaccine when it's injected into people being vaccinated. Subsequently, the body produces protective antibodies to develop immunity to the injected virus fragments (antigens). The Flublok influenza vaccine is manufactured this way, for example (see below).

However, the "new" gene therapy technology injects the synthetic virus/plasmid/mRNA directly into people being "vaccinated", skipping the bioreactor, target virus fragment reproduction, extraction, and purification steps, and instead uses the human body directly as the "bioreactor". This is a technique heretofore never tried before, yet the plans are to try this on billions of people all at once. However, this gene therapy "vaccine" technology is not even really a new technology at all because it's been around for a while, but big pharma knew that they could never get away with such gene therapy experimentation on billions of people UNTIL COVID came along and the FDA could eliminate the bulk of their previous vaccine safety requirements because COVID emergency ...

I for one do NOT wish to participate in this experiment ...I think I'll wait a few years and see how millions of other people react first ...

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This is how FluBlok influenza vaccine (a conventional recombinant DNA/RNA vaccine) is made:

https://sanofiflu.com/pdf/Flublok-Quadrivalent-Flashcard.pdf

[faithhopecharity]

There are also several more vaccines in the works from labs in U.K., Russia, communist China, Israel, and possibly more.

[Honorary Serb]

The AstraZeneca and J&J vaccines are NOT mRNA products, nor are they designed to invade the cells of the body.

I do not yet believe mRNA vaccines until I see GOOD clinical trial evidence (which is needed for any vaccine anyway). But I believe that there will be at least one vaccine that is deemed safe and effective by the FDA and equivalent European agencies by January 2021 or so, with the trials published in leading medical journals.

When that occurs, I intend to take that vaccine, and to recommend that others do so. Then we can end the totalitarian nonsense that says that a STUPID MASK is as good as a vaccine, such as was promulgated last week!!!!

[JimRed]

How do I get to try one?

[Engraved-on-His-hands]

The development of a Covid-19 will be important for public perception and the reopening of the economy, in addition to protection from Covid. However, since the epidemic appears to be on the decline, and since most of the Covid-19 deaths have been comorbidities, it is probably even more important to get the flu and pneumonia vaccines.

[gas_dr]

There are 330M people in this country. Polling indicates on the worst day that 50% of people would take the vaccine. This means 150M vaccines would be required. Why people engage in verifiably incorrect statements (which I assume is simply hyperbole) is beyond me.

[2aProtectsTheRest]

They’ve had nearly 100,000 volunteers between the three candidates listed who signed up to take a vaccine that wasn’t even approved by the FDA yet. No signs of any difficulty finding people ready to jump right in.

Once FDA approval has been granted following the results of phase 3 trials where tens of thousands of closely monitored volunteers have been testing a vaccine for several months, people will flock to receive a dose.

[2aProtectsTheRest]

Forget it, he spams that same fearmongering nonsense to every thread mentioning vaccines.

Just more fearmongering from Team Biden, trying to scare people away so they won’t give President Trump the credit he deserves for Operation Warp Speed.

[Honorary Serb]

I’m quite aware of the fear-mongering propaganda of the commies and Biden, which the anti-vaxxers exacerbate, to the detriment of us all!!!!

I still prefer the one-shot J&J vaccine—PROVIDED it is proven safe and effective in Phase 3 clinical trials, approved by the FDA, and published in leading medical journals. As a bonus, this vaccine is Bill Gates-free!!!!

THEN, I want us to all take the vaccine, and get back to NORMAL—NOT “new normal”—with a reelected Trump administration and hopefully a Republican Congress!!!!

[catnipman]

“The AstraZeneca and J&J vaccines are NOT mRNA products”

the AstraZeneca is however a synthetic virus with COVID DNA inserted for the covid spike protein, and like the mRNA vaccines it does invade the cells and hijacks the ribosomes and forces your body to manufacture the covid spike protein, just like the other two mRNA vaccines listed in the article ...

in other words, all three of the vaccines mentioned as being in Phase 3 fundamentally do the same thing: they hijack the ribosomes in the cells to manufacture the spike protein antigen, whereas conventional vaccines inject the antigen itself ...

whatever the J&J vaccine is,i wasn’t referring to it: I was just referring to the “3 Coronavirus Vaccines in Phase 3 Clinical Studies

[catnipman]

“Forget it, he spams that same fearmongering nonsense to every thread mentioning vaccine”

which part is “nonsense”?

[2aProtectsTheRest]

Most of it. Here’s a breakdown from an earlier response I gave to you: https://www.freerepublic.com/focus/news/3880175/posts?page=50#50

But I can see you’ve adjusted some of your copy-and-paste text, so I’ll add a few things.

“those quickie COVID “vaccines””

They’re not “quickie”. They’re going through the same safety and efficacy testing process as any other drug or vaccine. And getting faster at producing candidates is not new. In the early 20th century, it took decades to come up with a viable vaccine candidate. In the 1990s, it was down to under 5 years. By 2003 (SARS 2003), viable candidates were produced in 20 months. By 2014 with Ebola, it was down to 7 months. By 2016 with Zika, it was down to 6 months. Now in 2020, with the entire world’s efforts directed at the task, we got it done in 2 months.

This isn’t some rush job, much as the Democrats (and some people who call themselves pro-Trump) claim. This is the culmination of a century of incremental progress where we got a little bit faster as our knowledge, understanding, and available tools improved.

“are really vaccines in the traditional sense of a vaccine that injects target virus fragments (antigens) that the body reacts to by making protective antibodies.”

That’s NOT a traditional vaccine at all. A traditional (gen 1) vaccine would be injecting inactivated or weakened forms of the pathogen into the body. And plenty of the COVID-19 vaccine candidates do EXACTLY that. Here’s a list of them: https://www.who.int/docs/default-source/coronaviruse/novel-coronavirus-landscape-covid-19-(3)4b6debde1bdc4a85ae67d4ce578be1bf.pdf?sfvrsn=57c0b234_3&download=true

The problem is that’s slow and difficult to do. The second gen vaccines like Hepatitis B, Pertussis (Whooping Cough), Meningitis B, and others take the antigen and attach it to another harmless virus (usually something that can’t replicate in humans). That’s the most common COVID-19 vaccine candidate type. They’re not as slow to make as gen 1 vaccines, and they’re less dangerous (no risk of a bad batch like what happened with the Cutter Incident). But they do still take time to produce and sometimes result in allergies depending on how they’re cultured.

“programmed to invade the cells in our body and hijack their protein production machinery, namely the ribosomes”

There’s nothing “programmed” here. The mRNA platform uses a simple lipid shell. There’s no “programming” If it bumps into the right structure (the cell membrane for most cells), the lipid shell essentially melts into the membrane, releasing the messenger RNA inside the cell.

And there you go with that “hijack” word again, attempting to put ominous tones to something that’s completely normal and harmless. Ribosomes takes messenger RNA presented to them and build whatever protein is encoded. Nothing is being “hijacked”. And the glycoprotein being built (the SARS-CoV-2 antigen) is harmless. But the immune system recognizes it as foreign and that sparks a T-cell and B-cell response, which results in lasting immunity. These are all GOOD things.

“Instead, what these quickie “vaccines” really are is a giant gene therapy experiment to be conducted simultaneously on billions of people.”

False. This is where you jump the shark. There’s no “gene therapy” going on. There is no mechanism for ANY alteration of ANY DNA in any human cell with ANY of the vaccine candidates. You’ve literally made this up out of nothing.

“The Flublok influenza vaccine”

Your graphic doesn’t show what you think it does, or you’re being dishonest about it. They grow (technically culture) the antigens in proprietary host cells in a laboratory. NOT in human beings. NOT in anyone receiving the vaccine. They just need to produce tons of antigens for their particular vaccine.

This is completely different from the Moderna mRNA approach. One has NOTHING to do with the other. There is NO vaccine candidate for COVID-19 or any other disease which has ANY mechanism to edit human DNA. Does not exist. Zero evidence to support that it exists. Claim is utterly false and without merit.

[catnipman]

i went back and checked your posting history on vaccines and noticed that you called everyone you disagreed with a “fear-monger” ...

[catnipman]

“programmed to invade the cells in our body and hijack their protein production machinery, namely the ribosomes”

“The mRNA platform uses a simple lipid shell. There’s no “programming” If it bumps into the right structure (the cell membrane for most cells), the lipid shell essentially melts into the membrane, releasing the messenger RNA inside the cell.” = “programmed to invade the cells in our body”

“Ribosomes takes messenger RNA presented to them and build whatever protein is encoded.” = “hijack the cell’s ribosomes”

[2aProtectsTheRest]

I call posts that claim nonsense meant to strike fear into people fearmongering, regardless of the subject matter. But even moreso when that nonsense is ripped straight from the Democrats’ 2020 playbook. Calling the vaccines rushed, dangerous, and so on. All it does is serve to take away from one of the pillars of President Trump’s reelection campaign: ending COVID-19.

Stick to facts and avoid Democrat talking points that attack President Trump’s reelection campaign and we’ll get along famously. Try spreading misinformation intended to instill doubt in what President Trump is trying to do for the country and I’ll be right here to correct the record.

[2aProtectsTheRest]

I’ll take language designed to make innocuous things sound nefarious in order to spread fear for 500, Alex!

You’re coloring the language to turn this into something it isn’t.

[catnipman]

“You’re coloring the language to turn this into something it isn’t.”

as are you with your: “it bumps into the right structure (the cell membrane for most cells), the lipid shell essentially melts into the membrane”

“bumps into”

“melts into the membrane”

ROTFLOL!

don’t every recall seeing that kind of language in any biomolecular text books ...