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To: 2aProtectsTheRest

Here is the study in cats

Early Death after Feline Infectious Peritonitis Virus Challenge due to Recombinant VacciniaVirusImmunization.

“FIP virus(FIPV),has been identified as member of the family Coronaviridae.”

https://jvi.asm.org/content/jvi/64/3/1407.full.pdf

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179 posted on 08/19/2020 1:57:01 AM PDT by Polynikes ( Hakkaa paalle)
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To: Polynikes

Thank you for the study link. That explains why I couldn’t find anything about a vaccine killing cats.

The study you’ve linked doesn’t involve a vaccine killing cats. What it does involve is a weak antibody which enables easier cell entry by the virus in question. This is known as antibody-dependent enhancement. In this case, they took a deadly cat disease and created a vaccine that works poorly. The cats were then purposely infected to test the vaccine and it was found that the disease was able to work more quickly on the cats.

So two things to note: 1) this was NOT an mRNA (generation 3) vaccine. It was nothing like Moderna’s vaccine candidate for SARS-CoV-2. This vaccine was created by taking another unrelated virus (the vaccinia virus) and splicing in instructions for the antigen found on the surface of the virus they were trying to vaccinate the cats against (FIP virus). What that means is that when the modified vaccinia virus replicates, the new copies will all have the same glycoprotein on their surface as the FIP virus. The vaccinia virus would itself be harmless to the cats, but their immune system could form a response to the antigens present and potentially give them immunity to the FIP virus. However, this was 1989, so they were stuck with the tools available and apparently made a poor antigen.

2) The vaccine didn’t kill any cats. Those cats would have been just fine with the vaccine. However, once they were infected with the FIP virus, it was found that the virus was more easily able to replicate in their systems and an already fatal infection became fatal more rapidly because of the poor antibodies.

So this study has no implications for Moderna’s vaccine candidate whatsoever and it has no implications for human vaccine trials. This was an experiment done on cats in 1989. It ended poorly. I’m not worried about it and you shouldn’t be either.


180 posted on 08/19/2020 2:45:16 AM PDT by 2aProtectsTheRest
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