[SunkenCiv]

There’s plenty of evidence that syphilis was not present in the “old world” prior to 1492. It’s well discussed in another topic around here (linked above). It poses a bit of difficulty for those like me who recognize the evidence for a great antiquity for oceanic navigation. Syphilis appears to have been homegrown in isolation in the “new world”.

[Varda]

Not necessarily, they're still debating it.

Europeans could have been infected with syphilis before Columbus set sails to America