Prednisone has many issues to deal with by itself.Remember comedian Jerry lewis? He entered rehab to get away from prednisone addiction.
https://www.youtube.com/watch?v=wzfFFnbB-jw
Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases.
The problem of course with Covid-19 is it is a “novel” Virus which the human body does not recognize, and because of this, the immune system tends to overreact and try to muster everything it has to fight the invader which also harms normal cells ( much like a soldier shooting indiscriminately at anything ).
The way I understand it, Hydroxychloroquine and Prednisone serves to modulate the immune system’s response so that it does not overreact, giving healthy cells a chance to recover.