“Why not use aspirin if inflammation control is the goal? Is it not the “Holy Grail” of anti-inflammatories?”
I believe aspirin can make cytokine storms worse.
Although inhibitors of cyclo-oxygenase blunt PGE2-mediated symptoms such as fever and pain, we conclude that short term use of either aspirin or ibuprofen results in a 'rebound' increase in cytokine-induced cytokine synthesis that is not observed in LPS-induced cytokines.