Posted on 05/23/2020 11:30:13 AM PDT by null and void
Background
Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), none have yet been shown to be efficacious.
Methods
We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days. The primary outcome was the time to recovery, defined by either discharge from the hospital or hospitalization for infection-control purposes only.
Results
A total of 1063 patients underwent randomization. The data and safety monitoring board recommended early unblinding of the results on the basis of findings from an analysis that showed shortened time to recovery in the remdesivir group. Preliminary results from the 1059 patients (538 assigned to remdesivir and 521 to placebo) with data available after randomization indicated that those who received remdesivir had a median recovery time of 11 days (95% confidence interval [CI], 9 to 12), as compared with 15 days (95% CI, 13 to 19) in those who received placebo (rate ratio for recovery, 1.32; 95% CI, 1.12 to 1.55; P<0.001). The Kaplan-Meier estimates of mortality by 14 days were 7.1% with remdesivir and 11.9% with placebo (hazard ratio for death, 0.70; 95% CI, 0.47 to 1.04). Serious adverse events were reported for 114 of the 541 patients in the remdesivir group who underwent randomization (21.1%) and 141 of the 522 patients in the placebo group who underwent randomization (27.0%).
Conclusions
Remdesivir was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19 and evidence of lower respiratory tract infection. (Funded by the National Institute of Allergy and Infectious Diseases and others; ACCT-1 ClinicalTrials.gov number, NCT04280705. opens in new tab.)
It significantly cut the length of illness and the death rate. So significantly that the study was unblinded early. Yes you have to be hospitalized to get it. Those that are not ill enough to be hospitalized recover without intervention
ecausd hydroxychloroquine has not only been shown to be ineffective in hospitalized patients it has actually been shown to be harmful. That’s why
Higher chance of side effects for those not given the drug
OK, but again, it isn't "effects", it's "events".
Hospitalized Covid-19 patients have lots of adverse events whether they're taking Remdesivir, the placebo or neither.
No matter, the recommendation to unblind the study wasn't based on the adverse event data but on a 4 day faster recovery.
If my doctor offered me that I wouldn't hesitate.
The other puzzling thing is that a placebo is supposed to be basically an inert factor, yet they attribute two cases of "side effects" to the placebo.
Yeah, I wonder if it was a complication from the IV. Some people have bad reactions to injections, period.
“ecausd hydroxychloroquine has not only been shown to be ineffective in hospitalized patients it has actually been shown to be harmful. That’s why”
Aww come on now.... you mean to tell me that after 100’s of positive outcomes from the use of HCQ you’re still maintaining your position that HCQ is not worth the “risk” for the bulk of humanity?
i am maintaining it has been shown to be ineffective and likely harmful in hospitalized patients. Facts are pesky things
“i am maintaining it has been shown to be ineffective and likely harmful in hospitalized patients. Facts are pesky things”
I will concur with respect to hospitalized patients as they should have received HCQ “cocktail” at the onset of symptoms.
I am looking forward to seeing studies on that one
How to make quinine, very simple.
Fight the corona virus, just incase you may have forgotten, and don’t forget to take it with Zinc as this will mainline the quinine straight into your cells. And there still is BHT which keeps on disabling lipid coated viruses such as the corona virus.
Even if the media attempts to downplay the effectiveness of HCQ short for hydroxychloroquine it has been proven to be effective especially if taken along with zinc.
Pharmaceutical companies don’t want to touch it as its patents have run out and it is inexpensive to produce. Whereas they much rather try to come up with something which eventually can result in millions of Dollars in profit. A good example is HCQ with an approximate cost of $ 0.75 versus Remsidivire from Gilead for around $ 1000.00 and questionable results at best.
It also may be interesting to note that to date, there has never been a successful coronavirus vaccine made, due to the nature of the virus. Past attempts to create a coronavirus vaccine have ONLY RESULTED IN LEAVING THE VACCINATED PERSON WITH A HIGHER CHANCE OF SERIOUS ILLNESS AND DEATH WHEN LATER EXPOSED TO ANOTHER STRAIN OF THE VIRUS. Not to mention that this virus mutates and any vaccine suitable for one strain may lose its effectiveness for another.
So, in the meantime if you happen to be ambitious enough you may be able to concoct your own Quinine in a few simple steps.
In the kitchen, all you need is a pot on the stove. And some grapefruit peels. Quinine — as in “tonic with quinine” — can be made from boiling the rinds of a couple ripe grapefruits under a few inches of water, letting it evaporate against a glass-topped pot; simmering that airtight for two hours, then recover all the liquid once it cools. Voila. A process very similar to making a tincture, in this case using hot water to extract the medicinal component from the grapefruit rinds.
Sweeten with honey; take a tablespoon every few hours to bring up the phlegm. Or, pour a cup of it, sweeten liberally, mix with OJ or drink as tea. Swallow some zinc pills, it mainlines the quinine straight into your cells. (Or, for the gentlemen, mix it with seltzer water, and take it with your favorite gin.)
Forget the store bought “tonic”, even if it weren’t so fake, you’d need a dozen liters a day to get the effect. But think back to when “gin and tonic” was in its heyday, 1800s India, where the combo dulled the senses, but also fought off malaria.
Wow, only 20% liver damage, yet I think the Dr. Zelenko, HCQ treatment has less than 1% serious consequences. Nevertheless, now that Trump says he is using HCQ (and Zinc) prophylacticly, the media (big Pharma?) is now touting how dangerous it is.
Dr. Zelenko in his message to Trump reported April 7th said: “Dear Mr. President: I humbly suggest the following: 1. It is essential to start treatment against Covid-19 immediately upon clinical suspicion of infection and not to wait [multiple days] for confirmatory testing. There is a very narrow window of opportunity to eliminate the virus before pulmonary complications begin. The waiting to treat is the essence of the problem” [people ending up in hospitals on machines]. Items in brackets [ ] are my words.
Does this answer the issue? HCQ works best as an outpatient treatment before hospitalization becomes needed. Then other kinds of treatment are needed, unfortunately.
i would like to see studies outpatient treatment proving whether it is effective or not. The jury is still out on that one
Yes, I too would like to see studies on the many people Dr. Zelenko has treated. Also others like 1000 people in a high level Covid area or nursing homes. Status of Vitamin C, D3, and zinc levels before illness, and then levels 2 days after illness and a week after illness. Of course, you would need levels on a lot more people to allow for 1000 to actual be studied after illness. It would then be useful to compare their pre-illness levels with those who did NOT get sick at all. Then we could consider what immune enhancing levels of supplementation ought to be recommended.
I realize this is an old thread....but I am in a discussion with a liberal relative of mine about HCQ.
Are you saying you would not prescribe HCQ with zinc and the antibiotic that has been recommended to be taken with it if you had a patient in the early stages of COVID19?
Thanks.
i don’t treat people until they are hospitalized so i have a little different perspective. currently the standard is decadron + remdesivir +/- convalescent plasma for hospitalized patients. that said hcq is getting another look after the Ford study Treatment literally changes sometimes daily but we are making progress
azithromycin is used if we think there might be a secondary or atypical pneumonia on top of covid or until cultures are negative. Same with other antibiotics
Thanks for answering my question.
And thanks for being on the “front line” of seeing COVID19 patients in the hospital.
Glad HCQ is getting a closer look after the Ford study.
Are you seeing recoveries after the treatment you described?
Yes. the majority recover just fine unless there are extenuating circumstances
That’s good to know - thanks!
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