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Remdesivir for the Treatment of Covid-19 — Preliminary Report
New England Journal of Medicine ^ | May 22, 2020 | Multi member team

Posted on 05/23/2020 11:30:13 AM PDT by null and void

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To: Sacajaweau

It significantly cut the length of illness and the death rate. So significantly that the study was unblinded early. Yes you have to be hospitalized to get it. Those that are not ill enough to be hospitalized recover without intervention


21 posted on 05/23/2020 2:05:25 PM PDT by Mom MD
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To: Vlad The Inhaler

ecausd hydroxychloroquine has not only been shown to be ineffective in hospitalized patients it has actually been shown to be harmful. That’s why


22 posted on 05/23/2020 2:06:54 PM PDT by Mom MD
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To: silverleaf

Higher chance of side effects for those not given the drug


23 posted on 05/23/2020 2:07:39 PM PDT by Mom MD
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To: Steve_Seattle
I misspoke when I described the adverse effects as "side effects," but the difference between the two groups (21.1% versus 27%) does not seem "significantly fewer" to me; it seems attributable to chance or - at best - some slight benefit that might also be obtained from many other treatment options.

OK, but again, it isn't "effects", it's "events".

Hospitalized Covid-19 patients have lots of adverse events whether they're taking Remdesivir, the placebo or neither.

No matter, the recommendation to unblind the study wasn't based on the adverse event data but on a 4 day faster recovery.

If my doctor offered me that I wouldn't hesitate.

The other puzzling thing is that a placebo is supposed to be basically an inert factor, yet they attribute two cases of "side effects" to the placebo.

Yeah, I wonder if it was a complication from the IV. Some people have bad reactions to injections, period.

24 posted on 05/23/2020 2:34:04 PM PDT by semimojo
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To: Mom MD

“ecausd hydroxychloroquine has not only been shown to be ineffective in hospitalized patients it has actually been shown to be harmful. That’s why”

Aww come on now.... you mean to tell me that after 100’s of positive outcomes from the use of HCQ you’re still maintaining your position that HCQ is not worth the “risk” for the bulk of humanity?


25 posted on 05/23/2020 2:46:08 PM PDT by LastDayz (A blunt and brazen Texan. I will not be assimilated.)
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To: LastDayz

i am maintaining it has been shown to be ineffective and likely harmful in hospitalized patients. Facts are pesky things


26 posted on 05/23/2020 2:48:32 PM PDT by Mom MD
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To: Mom MD

“i am maintaining it has been shown to be ineffective and likely harmful in hospitalized patients. Facts are pesky things”

I will concur with respect to hospitalized patients as they should have received HCQ “cocktail” at the onset of symptoms.


27 posted on 05/23/2020 3:01:00 PM PDT by LastDayz (A blunt and brazen Texan. I will not be assimilated.)
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To: LastDayz

I am looking forward to seeing studies on that one


28 posted on 05/23/2020 4:14:43 PM PDT by Mom MD
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To: null and void

How to make quinine, very simple.

Fight the corona virus, just incase you may have forgotten, and don’t forget to take it with Zinc as this will mainline the quinine straight into your cells. And there still is BHT which keeps on disabling lipid coated viruses such as the corona virus.

Even if the media attempts to downplay the effectiveness of HCQ short for hydroxychloroquine it has been proven to be effective especially if taken along with zinc.

Pharmaceutical companies don’t want to touch it as its patents have run out and it is inexpensive to produce. Whereas they much rather try to come up with something which eventually can result in millions of Dollars in profit. A good example is HCQ with an approximate cost of $ 0.75 versus Remsidivire from Gilead for around $ 1000.00 and questionable results at best.

It also may be interesting to note that to date, there has never been a successful coronavirus vaccine made, due to the nature of the virus. Past attempts to create a coronavirus vaccine have ONLY RESULTED IN LEAVING THE VACCINATED PERSON WITH A HIGHER CHANCE OF SERIOUS ILLNESS AND DEATH WHEN LATER EXPOSED TO ANOTHER STRAIN OF THE VIRUS. Not to mention that this virus mutates and any vaccine suitable for one strain may lose its effectiveness for another.

So, in the meantime if you happen to be ambitious enough you may be able to concoct your own Quinine in a few simple steps.

In the kitchen, all you need is a pot on the stove. And some grapefruit peels. Quinine — as in “tonic with quinine” — can be made from boiling the rinds of a couple ripe grapefruits under a few inches of water, letting it evaporate against a glass-topped pot; simmering that airtight for two hours, then recover all the liquid once it cools. Voila. A process very similar to making a tincture, in this case using hot water to extract the medicinal component from the grapefruit rinds.

Sweeten with honey; take a tablespoon every few hours to bring up the phlegm. Or, pour a cup of it, sweeten liberally, mix with OJ or drink as tea. Swallow some zinc pills, it mainlines the quinine straight into your cells. (Or, for the gentlemen, mix it with seltzer water, and take it with your favorite gin.)

Forget the store bought “tonic”, even if it weren’t so fake, you’d need a dozen liters a day to get the effect. But think back to when “gin and tonic” was in its heyday, 1800s India, where the combo dulled the senses, but also fought off malaria.


29 posted on 05/23/2020 5:17:55 PM PDT by saintgermaine (THE TIME TRAVELLER)
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To: silverleaf; Vlad The Inhaler; All

Wow, only 20% liver damage, yet I think the Dr. Zelenko, HCQ treatment has less than 1% serious consequences. Nevertheless, now that Trump says he is using HCQ (and Zinc) prophylacticly, the media (big Pharma?) is now touting how dangerous it is.


30 posted on 05/27/2020 10:20:21 PM PDT by gleeaikin
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To: LastDayz; Mom MD; null and void; All

Dr. Zelenko in his message to Trump reported April 7th said: “Dear Mr. President: I humbly suggest the following: 1. It is essential to start treatment against Covid-19 immediately upon clinical suspicion of infection and not to wait [multiple days] for confirmatory testing. There is a very narrow window of opportunity to eliminate the virus before pulmonary complications begin. The waiting to treat is the essence of the problem” [people ending up in hospitals on machines]. Items in brackets [ ] are my words.

https://internetprotocol.co/hype-news/2020/04/07/how-to-cure-coronavirus-an-exclusive-letter-to-donald-trump/

Does this answer the issue? HCQ works best as an outpatient treatment before hospitalization becomes needed. Then other kinds of treatment are needed, unfortunately.


31 posted on 05/27/2020 10:34:48 PM PDT by gleeaikin
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To: gleeaikin

i would like to see studies outpatient treatment proving whether it is effective or not. The jury is still out on that one


32 posted on 05/27/2020 10:41:20 PM PDT by Mom MD
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To: Mom MD; RummyChick; null and void; PA Engineer; All

Yes, I too would like to see studies on the many people Dr. Zelenko has treated. Also others like 1000 people in a high level Covid area or nursing homes. Status of Vitamin C, D3, and zinc levels before illness, and then levels 2 days after illness and a week after illness. Of course, you would need levels on a lot more people to allow for 1000 to actual be studied after illness. It would then be useful to compare their pre-illness levels with those who did NOT get sick at all. Then we could consider what immune enhancing levels of supplementation ought to be recommended.


33 posted on 05/27/2020 10:51:04 PM PDT by gleeaikin
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To: Mom MD

I realize this is an old thread....but I am in a discussion with a liberal relative of mine about HCQ.

Are you saying you would not prescribe HCQ with zinc and the antibiotic that has been recommended to be taken with it if you had a patient in the early stages of COVID19?

Thanks.


34 posted on 07/10/2020 2:37:15 PM PDT by Freedom'sWorthIt
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To: Freedom'sWorthIt

i don’t treat people until they are hospitalized so i have a little different perspective. currently the standard is decadron + remdesivir +/- convalescent plasma for hospitalized patients. that said hcq is getting another look after the Ford study Treatment literally changes sometimes daily but we are making progress

azithromycin is used if we think there might be a secondary or atypical pneumonia on top of covid or until cultures are negative. Same with other antibiotics


35 posted on 07/10/2020 3:05:24 PM PDT by Mom MD
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To: Mom MD

Thanks for answering my question.

And thanks for being on the “front line” of seeing COVID19 patients in the hospital.

Glad HCQ is getting a closer look after the Ford study.

Are you seeing recoveries after the treatment you described?


36 posted on 07/10/2020 3:37:18 PM PDT by Freedom'sWorthIt
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To: Freedom'sWorthIt

Yes. the majority recover just fine unless there are extenuating circumstances


37 posted on 07/10/2020 5:16:59 PM PDT by Mom MD
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To: Mom MD

That’s good to know - thanks!


38 posted on 07/10/2020 5:18:03 PM PDT by Freedom'sWorthIt
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