There may be more than one protocol that works. We should keep researching. Plus, there could be mutations.
GS-441524, like remdesivir, binds to the virus’s nucleotide chain as the RNA dependant RNA polymeras goes down the chain, synthesizing the nucleotide compnents that make up the nucleotide strand. This “transcription” process of the virus’s nucleotide will not change due to any mutation. Once the GS-441524 binds to the chain, the RNA dependent RNA polymerase is unable to further its process. That stops the duplication process and the virus is terminated.
However, those trying to create a vaccine, do have to worry about mutations. It is the vaccine that creates the antibodies that target the DNA components that are unique to the virus. If those components change from a mutation, those antibodies have no components to target.
That’s like saying let’s try to find something other than tetracycline for bubonic plague.
Tetracycline is the reason we don’t worry about bubonic plague.