so you are telling me that the FIVE steps mentioned (and I highlighted IN RED)for Remdesivir in the first sentence I highlighted is the same as the SEVEN steps I highlighted in red in the last sentence.
Oooo kay. Five equals seven. Not contradictory at all.
“so you are telling me that the FIVE steps mentioned (and I highlighted IN RED)for Remdesivir in the first sentence I highlighted is the same as the SEVEN steps I highlighted in red in the last sentence.
Oooo kay. Five equals seven. Not contradictory at all.”
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It’s confusing but not contradictory.
The 5 Remdesivir steps refers to the number of METABOLISM “steps” that Remdesivir undergoes, after it is intravenously infused into the patient, before part of it finally becomes “GS-441524 triphosphate” which is the active element that acts against the Covid-19’s virus. It’s good to know that one of the interim METABOLIC steps (of the 5 steps in Remdesivir’s metabolism) yields GS-441524.
Producing Remdesivir in a drug manufacturing facility requires 7 STEPS before the Remdesivir is yielded.
Compared to Remdesivir, GS-441524 only requires 3 steps (versus 5 for Remdesivir) until the body has METABOLIZED it into the needed active form “GS-441524 triphosphate”.
And manufacturing GS-441524 takes only 3 STEPS (versus 7 for making Remdesivir).
I think the authors (or perhaps one of their commenters) said that because GS-441524 is a smaller molecule than Remdesivir and is soluble in water it would be given by sub-cutaneous injection and possibly could also be delivered directly to the lungs as an aerosol.