The authors point out that Remdesivir isn’t Gilead’s only antiviral nucleoside analogue. Gilead has also developed GS-441524, another pro-drug that, as its name suggests, the body also converts into GS-441524 triphosphate. As far as drug production goes, GS-441524 is easier to synthesize than remdesivir, requiring only three steps instead of the seven needed for remdesivir.
After reading the linked article I have to ask why Gilead is running to market Remdesivir instead of GS-441524 (a drug both easier to make and more effective than Remdesivir). Beats me. Perhaps because GS-441524 could have fewer years of patent protection remaining?
But the whole point of releasing the virus, at least from Fauci’s and Gates’ point of view, was to sell Remdesivir.
Why start a global plague if you can’t get rich off it? What would be the point?
The more time that passes, the more weight is granted to my hypothesis that the key to preventing complications in those
at-risk is elimination of the virus in the lungs. Such an approach would lower the odds of dying from SARS-CoV-2 infection to a mere fraction of the odds of dying in a vehicle crash
for the entire population, not just the young & healthy.
To-wit:
"Remdesivir’s lackluster results in patients with advanced Covid-19 in the NIAID-sponsored trial and the finding that it provided no statistically significant benefit in a clinical trial conducted in China among patients with severe Covid-19 symptoms are likely due to the suboptimal level of active GS-441524 triphosphate in the lungs. Patients with advanced or severe Covid-19 generally have a high viral load in their lungs and would need a high concentration of GS-441524 triphosphate to combat it.
The benefit of using GS-441524 over remdesivir is that GS-441524 can almost certainly be given at much higher doses due to its lower toxicity. This would result in more conversion to the active compound, GS-441524 triphosphate, in the lungs."
Btw:
Wuhan Coronavirus: Propylene Glycol as Possible Therapy for Eradication of RTI and Prevention of Complications [vanity]
But then again, fear is a useful tool, isn't it? /s