[SauronOfMordor]

The underlying first principle of science is the the Universe is understandable.

In practice, that it can be understood by a human-range IQ.

It remains to be seen if this is the case.

[Da Coyote]

Brings to mind:

“Now, my own suspicion is that the universe is not only queerer than we suppose, but queerer than we can suppose.”

first attributed to J.B.R Haldane

IMHO, this is going to be what we conclude - whenever.

[cornelis]

The underlying first principle of science is the Universe is understandable.

In other words, this thing called "Universe" is less inclusive than the totality of all things since it only concerns what knowable by a human-range IQ (whatever that is). So the term Universe is a bit of misnomer.

Learned this from the pagan Socrates.