“They also calculated the ratio of the tissue trough concentration to the CC50 (RTTCC) to compare the risk of toxicity of the two drugs in each tissue. They found that the RTTCC was 6-87 times higher for chloroquine compared to hydroxychloroquine for the lung, heart, kidney, and liver.”
“The PBPK model has shown that hydroxychloroquine has a better safety profile compared to chloroquine.”
As I keep pointing out, these two DIFFERENT drugs have different side effects. Why? Because they are DIFFERENT drugs!
The addition of the Hydroxyl group made the chloroquine safer, but did not change its active effect. Neither Aralen nor Plaquenil can be used without close doctor supervision.
I am not sure what is your point in emphasizing the differences between them. If my doctor elected to use Aralen instead of Plaquenil, I know of no reason to be concerned. In malaria and amoebiasis therapy the drugs have different dosages but are considered alternatives. Parasites resistant to one are resistant to the other.