The mechanism by which Remdesivir works is understood (relatively speaking) and demonstrated in vitro. It interferes with replication by causing substitution errors in the replication process. As one researcher, Maria Agostini, put it, “kinda like bringing the wrong twin home from summer camp.” There have been no animal studies or safety trials (please correct me) and of course no human clinical trials. There is persuasive anecdotal evidence as to its effectiveness in compassionate use.
The mechanism by which Chloroquine analogs are believed to work on a single strand RNA virus is not well understood, but the work being done has implications for “HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses.” (Dr. A. A. Al-Bari, 2016 see link below.)
—That CQ alone interfered with replication in vitro was observed, but not in animals.
—That Zn interfered with RNA dependent replicase in vitro was observed and is not in dispute, but the mechanism has not been explained in the popular YouTubes on the subject.
—That CQ/HCQ is a Zn ionophore is not in dispute.
—That HCQ opened epithelial cells for Zn to suppress replication was observed.
In order to be taken more seriously, this drug cocktail must be better explained or must be better tested. Testing will take time. People will die. It may fail the tests.
It IS being used, but in order to be used properly the theoretical mechanism should be better explained to clinicians without making promises of efficacy which cannot yet be established. It is important to note that there is no suggestion that this “kills the virus”. It possibly interferes with viral entry into susceptible cells and/or causes the disfunction of enzymes necessary for replication. “Inhibited glycosylation will therefore allow time for the adaptive immune response to deal with the infection (Baize et al. 1999).”
In other words, Mom MD observes that the results are unimpressive in the most serious patients. This is consistent with the theory behind HCQ and there is nothing in the most fanciful and idealistic conception of that theory to suggest that it would be otherwise. Neither would any other SOP Lopinavir/ritonavir, Remdesivir, or even the new ones being tried, EIDD-2801, and Avigan. It looks like the biologics might help the extreme patients survive but the ACE2 inhibitors may make it worse.
Read more about the mechanism of Chloroquine analogs:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461643/pdf/PRP2-5-e00293.pdf
Read more about treatments for COVID-19:
https://www.livescience.com/coronavirus-covid-19-treatments.html
More about remdesivir:
https://www.statnews.com/2020/03/16/remdesivir-surges-ahead-against-coronavirus/
Watch the video: https://www.youtube.com/watch?v=U7F1cnWup9M&feature
Beginning at 1 minute 40 seconds, about HCQ and ZINC
So let’s not dwell on the most severe patients for a second.
Let’s instead dwell on everyone wanting to go back to work. Why wouldn’t HCQ and Zinc be a potential prophylactic against the Wuhan Boogaloo? Why couldn’t we use that as a front line preventative and wait for whatever else comes down the pike as the backup for the most severe cases?
I’m also suspicious of vaccines that are funded by eugenicists.