Posted on 04/17/2020 6:20:15 AM PDT by RinaseaofDs
Yes as I said I am speaking to hospitalized patients only. This will likely take several different treatments for different stages and severity if illness. More than &0% of people will recover with no intervention at all
As I said I am speaking to hospitalized patients onku. Try to lost accurate information the death rate on hospitalized patients is nowhere near 70% and is likely not that high even in intubated patients
“More than &0%...”
__________________
Did you mistype 70% or what is the real number?
BTW my friend, Chris died on Tuesday. Thanks for your prayers.
‘Several different treatments for different stages’ ... and THAT is why Physicians, not laymen, treat the sick.
sorry. meant more than 80% will recover with no intervention.
The criteria for hospitalization is hypoxia and or a pneumonitis demonstrated on X-ray. In NYC/North Jersey these patients are almost all started on hydroxychloroquine and Zithromax. Some improve, some don’t and deteriorate. If they end up being intubated in respiratory failure the prognosis is very bad. Among patients who are intubated and in respiratory failure the death rate approaches 70%. the point is that it is best to begin Hydroxychloroquine/zithromax long before there is hypoxia and pneumonitis and long before a confirmatory COVID-19 test result is in hand. The politicians need to let ethical clinicians do what they need to do. They must stop unreasonable restraints on the prescription and dispensing of hydroxychloroquine.
I am well aware of the criteria for hospitalization I am treating this stuff regularly. x-day findings are not a criteria. Hypoxia and clinical risk factors are. In some places the mortality rate of intubated patients may approach 70% others I have heard 50% others less but it is never a good thing to be intubated. I hope it proves to be true that hydroxychloroquine given early or as prophylaxis makes a difference in the disease and I agree the government should stay out of it on either side but that is not what we are discussing here.
It costs more?
From what i've read, the suggested mechanism is that hydroxychloroquine is an ionophore that greatly increases cellular intake of Zinc, and it is the Zinc that is gumming up the virus's replication process.
The New York doctor that supposedly treated 600+ patients included Zinc Sulfate as part of his treatment.
If the theory is correct, the hydroxychloroquine will be considerably less effective if used in the absence of supplemental Zinc.
So true but either way they love their bloody hands!!
In theory, the raw swab would contain a mixture of DNA, RNA, lipids, and proteins. However, once the extraction process takes place, the DNA ends up discarded along with the proteins and lipids.
Just about any sample taken for analysis is going to have your DNA in it. I wouldn't worry too much about it.
The mechanism by which Remdesivir works is understood (relatively speaking) and demonstrated in vitro. It interferes with replication by causing substitution errors in the replication process. As one researcher, Maria Agostini, put it, “kinda like bringing the wrong twin home from summer camp.” There have been no animal studies or safety trials (please correct me) and of course no human clinical trials. There is persuasive anecdotal evidence as to its effectiveness in compassionate use.
The mechanism by which Chloroquine analogs are believed to work on a single strand RNA virus is not well understood, but the work being done has implications for “HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses.” (Dr. A. A. Al-Bari, 2016 see link below.)
—That CQ alone interfered with replication in vitro was observed, but not in animals.
—That Zn interfered with RNA dependent replicase in vitro was observed and is not in dispute, but the mechanism has not been explained in the popular YouTubes on the subject.
—That CQ/HCQ is a Zn ionophore is not in dispute.
—That HCQ opened epithelial cells for Zn to suppress replication was observed.
In order to be taken more seriously, this drug cocktail must be better explained or must be better tested. Testing will take time. People will die. It may fail the tests.
It IS being used, but in order to be used properly the theoretical mechanism should be better explained to clinicians without making promises of efficacy which cannot yet be established. It is important to note that there is no suggestion that this “kills the virus”. It possibly interferes with viral entry into susceptible cells and/or causes the disfunction of enzymes necessary for replication. “Inhibited glycosylation will therefore allow time for the adaptive immune response to deal with the infection (Baize et al. 1999).”
In other words, Mom MD observes that the results are unimpressive in the most serious patients. This is consistent with the theory behind HCQ and there is nothing in the most fanciful and idealistic conception of that theory to suggest that it would be otherwise. Neither would any other SOP Lopinavir/ritonavir, Remdesivir, or even the new ones being tried, EIDD-2801, and Avigan. It looks like the biologics might help the extreme patients survive but the ACE2 inhibitors may make it worse.
Read more about the mechanism of Chloroquine analogs:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461643/pdf/PRP2-5-e00293.pdf
Read more about treatments for COVID-19:
https://www.livescience.com/coronavirus-covid-19-treatments.html
More about remdesivir:
https://www.statnews.com/2020/03/16/remdesivir-surges-ahead-against-coronavirus/
One word.
MONEY.
Watch the video: https://www.youtube.com/watch?v=U7F1cnWup9M&feature
Beginning at 1 minute 40 seconds, about HCQ and ZINC
RinaseaofDs, ExDemMom
Thanks for the question & answers!
Bitt, ping to these posts:
https://www.freerepublic.com/focus/f-chat/3836032/posts?page=9#9
https://www.freerepublic.com/focus/f-chat/3836032/posts?page=42#42
https://www.freerepublic.com/focus/f-chat/3836032/posts?page=111#111
p
Plus 1 Bingo.
That study was HCQ alone.
The protocol being used now is HCQ/Zn/Azithromycin.
==
THAT ^^
Because of $$$$$.
Lots of people stand to make plenty, once Remdesivir is an approved treatment.
With the HCQ protocol? Not so much.
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