Posted on 04/12/2020 2:51:28 PM PDT by Factuality
Does anyone know the results, if any, of the hydroxychloroquine study that NY conducted? The last I heard was that NY was going to administer hydroxychloroquine to a test group of 1100.
Perhaps the result didn’t fit the narrative.
This might help a bit.
The New York Times SUBSCRIBE NOWLOG IN The Coronavirus Outbreak Latest Updates Tracking the Outbreak Common Questions What You Can Do Contribute to Our Reporting Newsletter Malaria Drug Helps Virus Patients Improve, in Small Study A group of moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed.
The study, which has not yet undergone peer review, was small and limited to patients who were mildly or moderately ill, not severe cases.
The study, which has not yet undergone peer review, was small and limited to patients who were mildly or moderately ill, not severe cases.
By Denise Grady April 1, 2020 The malaria drug hydroxychloroquine helped to speed the recovery of a small number of patients who were mildly ill from the coronavirus, doctors in China reported this week.
Cough, fever and pneumonia went away faster, and the disease seemed less likely to turn severe in people who received hydroxychloroquine than in a comparison group not given the drug.
The authors of the report said that the medication was promising, but that more research was needed to clarify how it might work in treating coronavirus disease and to determine the best way to use it.
“It’s going to send a ripple of excitement out through the treating community,” said Dr. William Schaffner, an infectious disease expert at Vanderbilt University.
The study was small and limited to patients who were mildly or moderately ill, not severe cases.
Like many reports about the coronavirus, it was posted at medRxiv, an online server for medical articles, before undergoing peer review by other researchers.
But the findings strongly support earlier studies suggesting a role for the drug, Dr. Schaffner said.
“I think it will reinforce the inclination of many people across the country who are not in a position to enter their patients into clinical trials but have already begun using hydroxychloroquine,” he said
Previous reports from China and France that the drug seemed to help patients, along with enthusiastic comments from President Trump, have created a buzz around hydroxychloroquine and the closely related chloroquine, which are decades-old drugs used to treat malaria and autoimmune diseases like lupus and rheumatoid arthritis.
A resulting spike in demand has led to hoarding and shortages, and left patients who rely on the drugs for chronic diseases wondering whether they will be able to fill their prescriptions.
With no proven treatment for the coronavirus, many hospitals have simply been giving hydroxychloroquine to patients, reasoning that it might help and probably will not hurt, because it is relatively safe.
The earlier reports from France and China drew criticism because they did not include control groups to compare treated versus untreated patients. Researchers called the reports anecdotal, and said the lack of controls made it impossible to determine whether the drugs worked.
Among health officials who declined to endorse the drugs, and who called for clinical trials, were some members of the president’s coronavirus task force — including Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, and Dr. Stephen Hahn, commissioner of the Food and Drug Administration.
The new study, of 62 patients with an average age of about 45, did have a control group.
It was conducted at the Renmin Hospital of Wuhan University, in Wuhan, China.
The patients were carefully chosen to exclude people with medical problems that could be made worse by hydroxychloroquine, like abnormal heart rhythms, certain eye diseases, and liver or kidney problems. Half the subjects — the controls — received just the usual care given to coronavirus patients, and half had usual care plus hydroxychloroquine.
The usual care included oxygen, antiviral drugs, antibiotics and other treatments.
Their disease was considered mild, even though all had pneumonia that showed up on CT scans.
After giving informed consent, they were assigned at random to either the hydroxychloroquine or the control group.
They were treated for five days, and their fevers and coughing were monitored. They also had chest CT scans the day before the study treatment began, and the day after it ended.
Coughing and fever eased a day or so earlier in the patients who received hydroxychloroquine, and pneumonia improved in 25 of 31, as opposed to 17 of 31 in the controls.
The illness turned severe in four patients — all in the control group.
Two patients had minor side effects from hydroxychloroquine: One had a rash and another had a headache.
Dr. Schaffner cautioned that the results applied only to patients with relatively mild illness, like the ones in the study, and could not be generalized to advanced cases.
“If you want to treat people who are already seriously ill, we don’t know how well this will work,” he said. If the drug is helping, it is not clear how.
There are two possible ways. In laboratory studies, it can stop the virus from invading cells.
But hydroxychloroquine can also dial back an overactive immune system, which is why it can treat autoimmune diseases.
And a powerful immune reaction to the coronavirus is suspected of playing a role in some of the severest cases of the disease.
“We don’t know which of the pharmacologic aspects of hydroxychloroquine are most active, the antiviral part, or the immunomodulatory part,” Dr. Schaffner said.
“We don’t know, but it does reinforce the notion, as the authors say briefly, it reinforces the thinking about the nature of many of these pneumonias we are seeing, which seem to have an immune basis, as opposed to being secondary bacterial pneumonia, which we see so often in influenza.”
Research coverage of coronavirus treatments Scientists Identify 69 Drugs to Test Against the CoronavirusMarch 22, 2020 image Oracle Providing White House With Software to Study Unproven Coronavirus DrugsMarch 24, 2020 image With Minimal Evidence, Trump Asks F.D.A. to Study Malaria Drugs for CoronavirusMarch 19, 2020 image The Coronavirus Patients Betrayed by Their Own Immune SystemsApril 1, 2020 image Denise Grady has been a science reporter for The Times since 1998. She wrote “Deadly Invaders,” a book about emerging viruses. @nytDeniseGrady More in Health Image Credit...Andrew Seng for The New York Times Why Are Some People So Much More Infectious Than Others? April 12, 2020 Coronavirus Live Updates: Oil Nations Agree to Cuts; Officials Weigh Risks of Reopening April 12, 2020 Dialysis Patients Face Close-Up Risk From Coronavirus April 11, 2020 Sign Up for NYT Parenting From the team at NYT Parenting: Get the latest news and guidance for parents. We’ll celebrate the little parenting moments that mean a lot — and share stories that matter to families. Sign Up ADVERTISEMENT Site Information Navigation © 2020 The New York Times Company Contact UsWork with usAdvertiseYour Ad ChoicesPrivacyTerms of ServiceTerms of SaleSite MapHelpSubscriptions Do Not Sell My Personal Information
And zero cardiac events. Zero. The gaslighters keep saying “Cardiac side effects!!! Need eeg before use!!!” and it’s complete BS. Rheumatologists give it out like candy, no eeg needed. No eye probs until YEARS of use, easy to catch, easy to correct.
We all should be on it as a preventative and get back to work!
Definitely let’s end this lockdown ! I’d leave preventative pills up to the individual ( probably unnecessary for most people, they can take the pills in the unlikely Che c’s they pick up the virus and it seems to do the job just fine then ). Either way, we need this damned lockdown like a dog needs fleas
That’s not how a clinical trial works.
It’s funny...they are not based on opinions.
Ask Fredo Cuomo.
CovidCuomo
RE: Fredo took it and he is fine now!
Please my friend, if you are being sarcastic or joking, say so.
That has to be the worst post I’ve seen here in years.
Dude!! Learn to do this right. For starters don’t cut and paste. Use your own words or just don’t post until you understand how it works. It’s really very simple.
Oh; and paragraphs are your friend.
I would not trust any information coming from China, research or otherwise. They lost their credibility long time ago.
Another one. Why not just post the link?
1. Where are the paragraphs? It doesn’t look this bad at the NYT.
2. NYT is supposed to be excerpted.
3. Why not just post a link to the NYT? Solves problems 1 and 2.
RE: Fredo took it and he is fine now!
Please my friend, if you are being sarcastic or joking, say so.
I am being factual, google it and you will see he is taking Quinine. (The original form of Hydrochloroquine). Google - what is Chris Cuomo taking to treat Covid19.
I’m not the posting police and I don’t play one on TV, but NYT articles are supposed to be excerpted.
Personally I feel it would have been a lot better to just post a link to the NYT article. Would have saved you lots of time and effort.
I see that they gave 450mg doses to a group of patients and 2 of them died from complications. Why start with such a high dose? My wife has been taking this stuff for Lupus for the past 35 years. She takes 250mg.
As I understand it...the ‘maintenance dose’ for those with Lupus or Rheumatoid Arthritis is fairly low....while someone with malaria might take a higher dose. [OTOH -those going into an area with malaria might take the lower dose as a prophylactic...to keep from getting malaria while in an malaria prone area.]
The dose scheme I recall for the COVID 19 was 200 mg x 3 times for the first day - then 200 mg x 2 for days 2 thru 6...and the Zn and ZPack also taken.
The higher dose was never shown to be a problem for malaria.
IMPORTANT NOTE - this treatment is REALLY effective if given ‘earlier’ - and one doctor in NY had 900 patients who used it...and less than 10 required hospitalization. Obviously if the treatment is not started until the person is in serious condition, it might be less effective. AND - patients who get placed on a ventilator are already seriously compromised...because the COVID-19 virus tends to shut down the immune system and it can cause organ damage. A treatment too late - is just that.
The NY doctor with 900 patients - had one die...and according to the reports, the patient did not follow the prescribed regimen.
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