Toss in the antibiotic azithromycin and it’s a winning trifecta treatment per all reports. This treatment is not a fancy new expensive “designer cure” but it works from all reports, and works quite well, nevertheless. For mere pennies, too.
My understanding, that I hope to confirm, is that hydroxychloroquine in addition to its anti-viral affects, ie., opening the zinc channel, has efficacy in suppressing some inflammatory cytokines. That would be a monumental finding given that most of the viruses that attack the lungs have the effect of initiating a cytokine storm in serious cases.
IOW, this medication could have far wider application and should be stockpiled and studied widely.
I believe it’s efficacy is against an over-expression of IL-6 and TNF (to be confirmed). One such confirmation is:
“In APCs, such as pDCs and B cells, this drug also inhibits antigen processing and subsequent MHC class II presentation to T cells, preventing T cell activation, differentiation and expression of co-stimulatory molecules (such as CD154) and also reducing the production of cytokines (such as IL-1, IL-6 and TNF) by both T cells and B cells. BAFF, B-cell activating factor.” from “Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology
Eva Schrezenmeier & Thomas Dörner
Nature Reviews Rheumatology volume 16, pages155–166(2020)Cite this article “
Another med that has promise in this area is Celebrex, a COX2 selective inhibitor, COX2 expression being a part of the inflammation process. Maybe a combination of those two drugs can have marked affect on cytokine storms, the typical killer in pandemic influenza, viral pneumonia, and ARDS (acute respiratory distress syndrome).