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I presume that many informed medical specialist are using their understanding of molecular biology to understand Covid-19 and postulate ways to apply therapeutic measures to diminish the negative impact to the disease. Dr. Zelenko mentioned that he had reviewed the experience in China, South Korea, France and Spain and came up with informed theories as how to treat infected patients.
This VIDEO [https://youtu.be/Eeh054-Hx1U?t=165] (15 min) explanation of the Covid-19 virus mechanism (somewhat technical) shows how the virus hijacks the normal cell “machinery”. The virus invades the cell cytoplasm (outer layer) and replicates vigorously to damage the (lung??) cell and also “bud off” (spread the virus, say through coughing) sending millions of new virus to infect human bodies. The key is how to stop/attenuate the replication of the virus when it enters the cell cytoplasm.

It turns out if the concentration of zinc in the cytoplasm can be increased the replication mechanism is attenuated. But how do you get the zinc into the cell? (Oral zinc will not do it!)
Remdesivir may work and here is why [https://youtu.be/Mm7UrZeu-74?t=240]. Random /blind studies are ongoing.

Another solution is to bring on the Zinc Ionophore [https://youtu.be/U7F1cnWup9M?t=93]. From a 2014 cancer study, research has indicated that CHLOROQUINE Diphosphate (used to treat malaria since 1955) will open a gate into the cell and then available zinc is transported into the cell, significantly increasing the intercellular zinc. The combination of chloroquine and zinc gets the desired effect – more zinc in the cell and the shutdown of the virus replication.

Papers have been published in China, South Korea, and France, and several tests/trials are ongoing in NYC. The MedCram doctors are encouraging randomized control trials, but at this time they are cautiously optimistic. With this background, it is understandable why Zelenko took the steps that he did to treat his patients. In time, the trials will tell whether this is treatment is “proven” to be a good approach to the disease.