[House Atreides]

Even five to ten grain (or about 324 to 648 mg) of aspirin tablets every three hours and more (up to 7 g within 24 hours) were prescribed to subdue fever ...
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Crimey... they might have subdued the fever at the cost of increased risk of internal bleeding.

[GulfMan]

> Crimey... they might have subdued the fever at the cost of increased risk of internal bleeding.

Aspirin Regimens (Dose and Schedule) Recommended in 1918 Are Now Known to Regularly Produce Toxicity. n 1977, a US Food and Drug Administration panel [22] recommended that the maximum safe daily dose of aspirin for the general population was 4000 mg, with a mean hourly rate of 167 mg/h Although these pathology findings have been induced with the 1918 influenza virus in models [6], they are also consistent with aspirin toxicity. A study of 177 adults with aspirin toxicity (and a 15% mortality rate) found the most common presentations were depressed consciousness (61%) and respiratory failure (47%), even “at therapeutic levels” [19]. Autopsy findings for patients with the 26 fatal cases were pulmonary edema (46%), ulcers (46%), cerebral hemorrhage (23%), and cerebral edema (31%). Coagulation disturbance or thrombocytopenia was found in 38%. A detailed autopsy of an adult with aspirin poisoning revealed cyanosis, pulmonary congestion, alveolar hemorrhage, subpleural and subepicardial hemorrhages, petechiae, cloudy swelling of the kidneys, and fatty degeneration of the liver [51, 52]. ARDS-like disease has also been reported [53]. Children with aspirin toxicity (or Reye syndrome) are less likely than adults to present with pulmonary edema [35], although in addition to brain swelling, fatty liver, and cloudy swelling of the kidneys [54, 55], some have pulmonary edema [55, 56], “frothy, blood-tinged fluid” [57], and lung hemorrhages [54].