found this, probably off one of these threads, (h/t to whomever posted this link) and I think this is what you were talking about some time back maybe?
If I’m understanding this paper right, if one gets a viral infection, and builds antibodies, and then gets a variation of that virus down the road, it may cause a more intense infection with that second variant.
maybe this is why a Wuhan person gets discharged as fine, but meanwhile the virus has mutated to a second or fifth generation or added some little bit of whatever along the way, and boom - now they’re in trouble:
” ... Khurana et al. characterized the antibodies associated with ADE in pigs vaccinated with whole inactivated H1N2 (human-like) vaccine and challenged with heterologous H1N1 virus (Khurana et al., 2013).
Sera from immunized pigs showed high titers of cross-reactive anti-H1N1 HA antibodies that were directed to the HA2 region but not the HA1 head, and these antibodies were associated with enhanced illness
....pre-fusion stem-directed antibodies are not likely to cause ADE. In fact, HA pre-fusion stem-only vaccine is considered a promising influenza vaccine that can induce broad protection. “
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290032/
Yes.
Dengue does this.
It’s probably the reason the SARS vaccine nearly killed the recipients when they were challenged with the virus a second time.