Even Mayo recommends up to 3200 mergatroids per day, while I take maybe 150.
I go by my own experience.
I have poor joints and have received two new shoulders, a knee they can't believe hasn't given out yet, a bad crooked toe they wanted to fuse, and a couple sets of (mostly unnoticeable) leg braces.
I spend an hour and a half in the gym every three days, do lots of stretches, 3 or 4 hundred stomach crunches, 40 pull-ups (GOOD pull-ups) and good hard ten minutes on the stairmaster.
I choose the latter because it is very low impact and mimics the motion I need to climb mountains and cross rivers, which I do quite a lot of.
By my own method I sleep well, wake refreshed, and don't let much of a damned thing slow me down.
That's all I can say.