[neverevergiveup]

Probably an interesting study, from a molecular biology perspective, but the relevance to human atrial fibrillation is likely tenuous, at best. First, zebrafish have very different physiological parameters as compared to humans. Second, atrial fibrillation in humans is a complex entity, and has many different potential causes - including atrial dilation and fibrosis (developing over time in response to hypertension, valvular disease, or other contributors). There are also genetic causes. In short, atrial fibrillation is a consequence of many potential contributing factors, and can be very different in causation in different people. Even binge drinking can cause it. The bottom line is that it is highly unlikely that an atrial fibrillation model in a zebrafish will be predictive of pharmacological success in humans.
Just sayin..

[zeestephen]

I agree.

It's not clear to me what relevance this has for humans.

Life long runners, like me, have 3-4 times the rate of A-Fib compared to non-runners.

Yet, most of us have no other cardio-pathology.

But, one thing did catch my attention in this article.

I had A-Fib symptoms in my early teens. USA doctors are very skeptical when they hear that.

It will be interesting to see if the requisite physiology for A-Fib is present in human children.