I once took one of my friends flying with me who was a big Microsoft Flight Simulator fan. He said that he had downloaded the profile for our plane and had used it quite a bit. He had memorized all of the speeds for take off, landing, cruising, etc. etc. and had a good understanding of everything about flying the plane. So I told him that I wasn’t going to give him any hints, just to take me for a ride, while I took care of the radio communications because I picked him up at an airport with a tower.
He did just great on take offs and landing and everything in between... He had never flown a real plane before.
I've been a pilot 50 years. I have Microsoft Flight Sim. I believe it's quite possible.
the 9/11 hijackers trained on flight simulator and didn’t even have to master taking off or landing.
My brother had a student who did the same thing with a Young Eagles pilot. She let him do the entire flight. He had never been in any plane before