Pence being the senate tie breaker would make that a poor strategic decision IMO.
If she changed parties, however, then perhaps.
I think she is clearly a better leader than Pence. I don’t have anything against Mike, but he doesn’t really move me. At least he hasn’t yet.
She wouldn’t have to change parties. Split tickets have happened before. (devil’s advocate here, I do not want to see her anywhere near the Office)