[Lizavetta]

Losing two of his children is enough. His wife lived to see three of her children die, and her husband.

If that doesn't craze you I don't know what will. I lost one and it changes your psyche and your brain forever.

[HollyB]

But the article states he suffered long before he was married. It seems to begin around the time of the death of Ann Rutledge.

[Levy78]

Yes. Saw the same in both parents when my sibling died unexpectedly at 30

[Magic Fingers]

“I lost one and it changes your psyche and your brain forever.”

It certainly does.