Seems like the Civil War decided this. The industrial North, which didn’t have slavery, overcame the slave-driven rural South with economics. We had indentured slavery from the colonists, but it was a black ‘owner’ who filed the court case ultimately legalizing involuntary slavery.
No, it overcame them with four times the population which could keep killing off it's young men at a rate far higher than the South could match.
Economics didn't win the war. Sheer numbers of able bodied men and a government willing to sacrifice them is what won the war.
It is entirely debatable whether the immigrant wage slavery of the north differed much from the chattel slavery of the south.