Posted on 07/03/2019 6:48:47 PM PDT by BenLurkin
Cannabis suppositories have grown in popularity, but how and to what extent they actually work remains a mystery. With contradictory claims from proponents and skeptics regarding the rectal bioavailability of THC, intoxication (or lack thereof), and alleviation of symptoms of difficult-to-treat diseases, it’s time to get a grip on what we really know about this method of administering cannabis.
Clinical research on cannabis suppositories is still limited. Much of the available data pertains to experiments conducted on animals, not on people who actually use suppositories. Despite the distinct lack of clinical studies, anecdotal accounts from patients are often very positive. The overwhelming majority of patient reports have one thing in common: a lack of intoxication that’s typically caused by smoking or ingesting THC-rich cannabis.
The absence of a “head high” would seem to indicate that a suppository does not distribute a systemic dose of cannabis – which corroborates initial research findings about limited bioavailability. This suggests that a suppository acts more like a topical with a local effect, rather than a transdermal patch which disseminates medicine systemically through the bloodstream.
Why suppositories?
Rectal and vaginal suppositories have both been used to deliver medicine to patients for decades. The pelvic region houses a matrix of nerves that travel to the legs and up the spine, and the colon contains cannabinoid receptors (CB1 and CB2), which mediate many of THC’s effects.
Generally, cannabis suppositories are made by combining cannabis-infused oils in a carrier oil that hardens at low temperatures. Rectal administration of cannabis oil may activate the cannabinoid receptors located there, which could be beneficial for local conditions like hemorrhoids or acute inflammation [6]. The rectum also contains a number of key veins that deliver blood to the entire body, but it doesn’t appear that suppositories facilitate cannabinoid absorption into the bloodstream.
(Excerpt) Read more at projectcbd.org ...
Funny!
Not my idea of pot brownies.
lol... I remember when tarballs were all the rage for this use.
It’s a Trainwreck waiting to happen.
Those were the days my friend, I thought they would never end...
bookmark
Why?
Work great for the dealers...
You can use a felching straw as a handy applicator
Sure, if you want to get your ass high!
Come on slow and lasts a Loooong time....
Just like glycerine...
Excellent
The Cheetos supositories are a bit more difficult to insert....
“Don’t Bogart they suppository, my friend.”
What is wrong with the good old tried and true vodka enema?
You’re smoking it wrong!
Gives a whole new meaning to “shotgunning”
they= that
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