Wild parsnip/giant hogweed is pretty notorious for causing this. As for margaritas, I found frozen limeade and tequila in pretty much equal measure hits the spot. No lime squeezing necessary.
Bacardi frozen margarita mix.
My hands swell and crack from a number of things. I burned one hand about ten years ago in an unfortunate camp stove incident and it seems to be extra sensitive.
I’ve noticed that citrus does it. So does fish. I don’t fish often v=but when I do, I wear latex gloves when handling them, otherwise they swell for a couple days.
I also notice it when handling some vegetation, like pushing aside branches when hiking.
That's why I've stopped putting it into my margaritas.
Regards,
Now Genesis will need to release a new song called "The Return of the Frozen Margarita."