My guess, and it's just a guess based on very little information...
There is a freon leak in their room. If they smoke, when they draw chlorofluorocarbon contaminated air through the coal on the cigarette, the heat breaks it down to carbon monoxide chloride - COCl2 - also know as phosgene.
On the battlefield, phosgene caused death by pulmonary edema. Other symptoms include nausea and vomiting...
All three were in the same resort, and all three had just opened bottles from the mini bar. The one lady that died while in her husbands arms went in a matter of seconds after taking a drink. She drank, yelled something, went into convolutions and died while he was trying to administer CPR, all in the matter of minutes.
The deaths there were intentional, they had to be.