Well, sure — speculate away, unless you’re a GOT staffer with inside knowledge.
Jon Snow and Dragon Lady should win. But that’s too pat. Peter Dinklage will use them, then cross them, and he’ll win. Possibly they will be figure heads while Dinklage becomes the Right Hand as the real power behind the Throne. Sansa will be Dinklage’s consort and Arya his enforcer. That’s my bet.