Here is just one recent paper you should read and please quit giving medical advice. New insights into the mechanisms of the ketogenic diet
I have many more if you are truly interested in learning.
Thank you for the excellent reference. It is an good description of how ketones compete with glucose in the Krebs Cycle.
I am very interested in your references as it will save me research time. Thanks.
I've been researching this as part of understanding the neuroscience of fasting, hemoglobin, hypoxia and VEGF. When ketones are used as fuel it decreases CO2 production due to where they enter the Krebs Cycle. Fascinates me.
I have a few useful online tools to help in searches. Some take time to figure out.
The first is
Protein Atlas. They generally keep it up to date with current findings. The protein abbreviations can be a bit challenging, however Wiki does a decent job of posting them.
The second is the
KEGG (Kyoto Encyclopedia of Genes and Genomes) website showing the different pathways with information on reactions. It is a bit clunky at times. Recently, they showed a change to a bidirectional reaction. There was no reference to it. That is one of the shortfalls of the database. Their numbering system can also be found in Wiki references.
An example would be "EC 1.8.1.3", hypotaurine dehydrogenase. Some information included is the metabolic pathway
Taurine and Hypotaurine Metabolism and reaction
RO1681. I chose that example because of the number of disease states resulting from disregulation of taurine an hypotaurine.
The third tool is the
STRING. This is useful for protein and gene interactions. Again, Wiki can help with the shorthand nomenclature of the search string.
For papers I use both the general search engine and
Google Scholar. For open source
SciHub is an invaluable website. Just cut and paste the article title in the search bar, hit search and type in the word shown (I am not a bot thing) and the paper will appear. The site is safe. You can then save it to the desktop. I also copy and paste their bibliography format when doing publication references. A few changes are required, however it saves a lot of work in a task no one on my team wants to do.
For medical searches I use
Unbound Medicine. The application is free and incredibly useful. I don't know about a Windows version.
The epilepsy paper I posted is a side project favor I am doing for a Neurologist on our team who is setting up a treatment clinic. Most of our work is related to a very rare childhood genetic disorder that expresses a very young onset of neurodegeneration. In a way, the disease is rapid aging model for diseases such as Parkinson's, Huntington's, Alzheimer and ALS. Type II diabetes age related brain disorders are also tied into this model. That is the reason we are looking at ketone metabolism (treatment) secondary to reversing or at least controlling the genetic defect.
If you would like me to post more or anything specific please let me know.