I only use Windows Defender and nothing else, because I’ve tried them all and there’s not that much difference between them.
I haven’t had any problems with Windows Defender interfering with Windows Updates and I haven’t had any virus or security breach on my Windows 10 OS.
I also use Windows Defender, but about every month or two, I run Trend Micro’s House Call (free). No single AV will catch everything. The typical AV looks for nasties less than a year to a year and a half old; House Call is a bit slower, but it’s because it looks for nasties going back many years. You need a new free copy every time you run it, but that’s OK, it’s free.