I'm guessing that orthopedic surgeons love a .460 Weatherby pistol - great for business. That pistol seems to be another example of just because you can do it doesn't mean that you should.
To answer your first question, I would say a caliber that is first popularized in a pistol and then migrates to a rifle.
A .41 magnum in a Ruger Blackhawk pistol and a companion Henry Big Boy carbine are on my wish list.
I have several friends that own .41 Mag revolvers. Both love them except for ammo availability and price. Not a problem if you reload.
My 45 Ruger Blackhawk has been my sidearm when hunting for 35 years now. I've thought of picking up a 45LC lever action, but I already had a 45-70, so never did.