Know the area well. This time of year is always a shoot as to the weather and road conditions. As a general rule loose elevation as fast as you can. The weather looks to be cold and dry for the next few days. I would be tempted to take 50 to 95 and go South. Guaranteed they are clear. 395 South of Topaz has some higher spots that will most likely be clear but may have icy patches since it doesn’t get sunlight this time of year.
You are the second to suggest 395 -> 50 -> 95 south. Although out of the way it may be the safest route.