Safest? Maybe, maybe not. There’s an interesting marketing campaign going on with Amazon. Prime members are being offered an opportunity to buy a limited number of tickets for showings a week ahead of the official opening. Don’t recall hearing this done before.
I say safest because the comic books movies are the main ones making any money for Hollywood. Over the last few years it seems the biggest box office seems to go the the comic book movies. And I generally lump the Star Wars movies into the comic book genre these days.
I just looked it up - in the last three years 5 of the top 10 grossing movies were comic book movies. That’s not including the animated Disney/Pixar type movies which would bump it up to 7 of the to ten if included. Comic book movies are a very safe bet.