Good scream chemistry at best is a hit or miss in most movies.
The best screen chemistry, in my opinion the best ever, was that between William Powell and Myrna Loy, 16 movies together, a record that will never be broken.
I never cared much for a lot of the Spencer Tracy-Katherine Hepburn pictures, some were great, some were not.
In any event I rarely see much real good chemistry in today’s films.
I am with you. The Thin Man: first major film franchise?
But my favorite WP is Life with Father with Irene Dunne.
Well, outside of real special effects....