The top seeds play unseeded players in the first and second round and lower seeded players (unless unseeded players cause upsets) in the next rounds.
Still begs the question - since she hasn’t been competing and the rest have, why does she deserve to be considered the top seed? If she’s still that good, she will claw her way back to the top - being the top seed should mean everyone else is chasing you because on any given day you will prevail...