Yes, 99.7% are. My niece - first her father, down the hill, then her - brought me an abandoned 3” abandoned runt calico who was hand-raised into the most gorgeous, crazy, funny functional human with cat characteristics last summer. Her name is TuKat Shapurr, because she’s literally ‘outta da grass’ begging tiny and blind to be rescued.
My son who is not a cat personal adopted a runt calico in January. He is now totally owned by her.