the presence of a gene or two pales in comparison to not accepting who one is... i can be a person who likes to arrange flowers but has a penis, a person that loves to field dress a deer, and where a dress. the problem i see is the mental dysfunction of not being happing with what one is born with and the need to change with a heavy regiment of drugs.
You are on it. Male is male, no matter how the individual expresses it.
There might be genes that are sensitive to the cause of gender dysphoria. Cause might be plastics in the environment, say, and one person might be more affected by the amount of plastics in his uterine environment than another by virtue of his genetic makeup.
But “transgender” can’t be genetic. It’s a concept. Males feeling like females is one thing but it doesn’t change their maleness.