The short answer is Yes.
Get Los Angeles and San Fransicko to openly rebel and then the whole state of California gets dragged into it. Then it would be on. They are in open rebellion already, as far as that goes. THEN what happens?
Ask President Lincoln.
Do other states join them?
Perhaps. Ask President Lincoln. What is critical is understanding what happens after the federal government restores order.
Under a civil war precedent still on the books, a precedent that the Supreme Court refused to consider in 1939, ten states were combined into five military districts. The states were stripped of their statehood until they fulfilled certain requirement set by Congress to be readmitted to the Union.
We could see something similar.